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Alyssa Milano Free Screensaver. Photos slideshow. Alyssa Jayne Milano (born December 19, 1972) is an American actress. Alyssa Milano is the daughter of American parents Lin, a fashion designer, and Tom, a film music editor. She is best known for her roles on the sitcom Who's the Boss? and on the supernatural series Charmed. Alyssa Milano has come a long way since her years as a child model and actress in the '80s sitcom Who's the Boss.